In what situation do mice typically cause the most economic loss?

Mice typically cause the most economic loss when they contaminate food supplies. Even a small number of mice can lead to significant waste and economic impact because they can spread diseases and pathogens through their droppings, urine, and fur. Contaminated food must often be discarded, leading to financial losses for food producers, processors, and retailers. Moreover, the presence of mice in food storage areas can raise health concerns, potentially leading to stricter regulatory scrutiny and loss of consumer trust.

While the other situations are factors to consider, such as breeding leading to population booms or consuming large quantities of grains affecting agricultural yields, the direct contamination of food supplies is the most immediate and economically impactful consequence of a mouse infestation.